I've done one epigenetic aging test, my DNAage. I was planning on doing a 2nd test, since I've added some longevity hacks since. Best recommendation (for retail consumer) for getting most accurate new epigenetic age?
Thank you for your interest and question! In my opinion, the Index test from Elysium Health performs the best, for reasons described in my post — it's based on a second-generation clock (while myDNAge is based on first-gen Horwath clock). Elysium/Dr. Levine are also actively improving their models for customers over time. That being said, Index is almost 2x the cost of myDNAge.
To my knowledge, not disclosing age doesn't remove the issue of the reproducibility of results. The preprint article I mentioned had deviations when the same sample was rerun for analysis. These deviations are agnostic to whether or not the experimenters were blinded to the chronological age of the participants' samples.
Thoughts? I am of course interested in both absolute accuracy and low variation. I am implementing a whole host of pro longevity interventions, and I am looking for an accurate aging tracker that has fundamental biological basis.
I see, yeah it's a great question. Index's model shouldn't rely on chronological age, as the PhenoAge clock was based on DNA methylation at 513 CpG islands + 9 biochemical markers: albumin, creatinine, glucose, C-reactive protein, alkaline phosphatase, lymphocyte percent, MCV, red cell distribution width, WBC count.
Don't think Index analyses plasma proteins though, even it's a saliva test.
I've done one epigenetic aging test, my DNAage. I was planning on doing a 2nd test, since I've added some longevity hacks. Best recommendation (for retail consumer) for getting most accurate new epigenetic age?
I've done one epigenetic aging test, my DNAage. I was planning on doing a 2nd test, since I've added some longevity hacks since. Best recommendation (for retail consumer) for getting most accurate new epigenetic age?
Thank you for your interest and question! In my opinion, the Index test from Elysium Health performs the best, for reasons described in my post — it's based on a second-generation clock (while myDNAge is based on first-gen Horwath clock). Elysium/Dr. Levine are also actively improving their models for customers over time. That being said, Index is almost 2x the cost of myDNAge.
Personal anecdotal evidence about variability b/w different tests (like this https://forum.age-reversal.net/t/g9h1hd0/variability-among-horvath-type-dna-methylation-age-tests) is consistent with the reliability problem I talk about. So I wouldn't be surprised if there is some technical noise switching between your first myDNAge result and a second Index result. Hope that helps!
(I don't have any affiliations with either company)
Does Elysium ask for your chrono age for the test? What if I don't disclose my age to remove this bias?
I don't believe Elysium asks for your birth date, it's not asked when you register your kit: https://ecom.elysiumhealth.com/en-us/account/index/register
To my knowledge, not disclosing age doesn't remove the issue of the reproducibility of results. The preprint article I mentioned had deviations when the same sample was rerun for analysis. These deviations are agnostic to whether or not the experimenters were blinded to the chronological age of the participants' samples.
Understood, I wasn’t inferring disclosing age on having any impact on deviation, but on the absolute epigenetic age result reported.
Also, appreciate the engagement and questions :)
A recent posting discussing the Morgan Levine approach.
https://joshmitteldorf.scienceblog.com/2021/09/06/a-new-approach-to-methylation-clocks/
Thoughts? I am of course interested in both absolute accuracy and low variation. I am implementing a whole host of pro longevity interventions, and I am looking for an accurate aging tracker that has fundamental biological basis.
I see, yeah it's a great question. Index's model shouldn't rely on chronological age, as the PhenoAge clock was based on DNA methylation at 513 CpG islands + 9 biochemical markers: albumin, creatinine, glucose, C-reactive protein, alkaline phosphatase, lymphocyte percent, MCV, red cell distribution width, WBC count.
Don't think Index analyses plasma proteins though, even it's a saliva test.
I've done one epigenetic aging test, my DNAage. I was planning on doing a 2nd test, since I've added some longevity hacks. Best recommendation (for retail consumer) for getting most accurate new epigenetic age?